08168958821
Home » Agriculture » INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOX...
INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE
Sold By: Joe Project Store | Item Type: Project Material | Report this? | Attributes: 55 pages | 1-5 chapters | Amount: ₦5,000 | Marked useful: 5,375 times
Delivery: Within 24 hoursINFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE
ABSTRACT
Type 2 diabetes mellitus (T2DM) is a chronic progressive disease that has continued to be a
global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting
alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is
widespread in plant foods and beverages such as tea and wine.This study therefore, sought to
investigate the influence of gallic acid on α-amylase and α-glucosidase inhibitory and antioxidant
properties of acarbose (in vitro). Aqueous solution of acarbose and gallic acid were prepared to a
final concentration of 25μM each. Thereafter, mixtures of the samples (50% acarbose + 50%
gallic acid; 75% acarbose + 25% gallic acid; 25% acarbose + 75% gallic acid) were prepared.
The results showed that the combination of 50% acarbose and 50% gallic acid showed the
highest α-glucosidase inhibitory effect, while 75% acarbose + 25% gallic acid showed highest α-
amylase inhibitory effect.
Furthermore, all the samples caused the inhibition of Fe2+-induced
lipid peroxidation (in vitro) in rat pancreatic tissue homogenate, with the combination of 50%
acarbose and 50% gallic acid causing the highest reduction in the malondialdehyde content. In
addition, all the samples showed antioxidant properties (ferric reducing property, 2, 2'-azino-bis
(-3-ethylbenzthiazoline-6-sulphonate (ABTS*) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH)
radicals scavenging abilities, and Fe2+ chelating ability). Therefore, the combinations of gallic
acid with acarbose could be employed in the management of T2DM with the comparative
advantage of possible reduction of the side effects of acarbose; nevertheless the combination of
50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of
type 2 diabetes mellitus.
This material content is developed to serve as a GUIDE for students to conduct academic research
Delivery: Within 24 hours
Advertise Here
Not what you were looking for? Perform a search
What's your project topic?
Comment on Facebook:
Related Project Materials
- 1.
EFFECT OF ANCHOR BORROWERS PROGRAMME ON POVERTY STATUS OF RICE FARMERS IN NIGERIA
CHAPTER ONE INTRODUCTION 1.1 Background of the study Agriculture served as the primary pillar of Nigeria's economy prior to the discovery of oil in...More »
Item Type: Project Material | 54 pages | 2,333 engagements |
- 2.
AN ASSESSMENT OF THE POTENTIAL BENEFITS OF THE ANCHOR BORROWERS' PROGRAMME FOR SMALL-SCALE FARMERS I...
AN ASSESSMENT OF THE POTENTIAL BENEFITS OF THE ANCHOR BORROWERS' PROGRAMME FOR SMALL SCALE FARMERS IN NIGERIA CHAPTER ONE INTRODUCTION 1.1 Backgrou...More »
Item Type: Project Material | 54 pages | 1,293 engagements |
- 3.
SIGNIFICANT CONTRIBUTIONS OF THE ANCHOR BORROWERS PROGRAMME TO THE PRODUCTIVITY OF RICE FARMERS IN E...
CHAPTER ONE INTRODUCTION 1.1 Background of the study Rice is a primary food source and makes up a significant part of the diet in many African nati...More »
Item Type: Project Material | 54 pages | 913 engagements |
- 4.
AN INVESTIGATION ON THE INFLUENCE OF THE ANCHOR BORROWER PROGRAM ON AGRICULTURAL COMMODITIES IN BIRN...
CHAPTER ONE INTRODUCTION 1.1 Background of the study The wide range of opportunities in the agricultural industry attracts increased attention from...More »
Item Type: Project Material | 54 pages | 2,106 engagements |
- 5.
AN INVESTIGATION OF THE IMPACT OF FLOODING ON AGRICULTURAL PRODUCTIVITY IN KADUNA STATE
CHAPTER ONE INTRODUCTION Background of the Study In the globalizing world today, Nigeria inclusive, the visible climate change impacts and global w...More »
Item Type: Project Material | 54 pages | 1,139 engagements |
- 6.
NATIONAL INSECURITY AND THE CHALLENGES OF FOOD SECURITY IN NIGERIA (BASED ON THE PRESIDENT TINUBU AD...
CHAPTER ONE INTRODUCTION 1.1 Background of the study Nigeria's primary objective in its agricultural renaissance is to diversify its economy by establ...More »
Item Type: Project Material | 54 pages | 1,699 engagements |